Iatrogenic Effects of COX-2 Inhibitors in the US Population

NSAIDs (non-selective non-steroidal anti-inflammatory drugs) are becoming a National Health Issue.

Big Brain Insights:

• Iatrogenic Cox 2 inhibitors = caused by the treatment of COX 2 inhibitors, like Aspirin, Tylenol, Advil, Motrin, as well as prescription brands like,Vioxx & Celebrex.
• This is an incredible article that might be so intense you wont want to believe it. But the facts in these article cant be ignores: Vioxx (rofecoxib) resulted in a 3x increase in acute heart infarction and 328x increase in GI bleeding. Tradition NASIDS (Aspirin, Tylenol, etc.) are associated with 138x increase in GI bleeding.
• Important point: patients with chronic pain attributed to spinal degenerative disease 59% can become pain/drug free and 29% can reduce their drug dependence by taking omega-3 fatty acids for 75 days. (Joseph Charles Maroon, MD, Jeffrey W. Bost, PAC; Omega-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti- inflammatory drugs for discogenic pain; Surgical Neurology; 65 (April 2006) 326– 331.)
• In the treatment of chronic neck and back pain, chiropractic spinal adjusting is better than 5x more effective than Celebrex or Vioxx, and the benefits of 9 weeks of chiropractic was still present a year later. Unlike the drugs, chiropractic was associated with no adverse events. (Lynton G. F. Giles, DC, PhD; Reinhold Muller, PhD; Chronic Spinal Pain:A Randomized Clinical Trial Comparing Medication, Acupuncture, and Spinal Manipulation; Spine July 15, 2003; 28(14):1490-1502. Reinhold Muller, PhD, Lynton G.F. Giles, DC, PhD; Long-Term Follow-up of a Randomized Clinical Trial Assessing the Efficacy of Medication, Acupuncture, and Spinal Manipulation for Chronic Mechanical Spinal Pain Syndromes; Journal of Manipulative and Physiological Therapeutics, January 2005, Volume 28, Number 1.)
• In a study of 50,276 consecutive chiropractic adjustments involving 19,722 patients, no serious adverse events occurred. (Thiel, Haymo W. DC, PhD; Bolton, Jennifer E. PhD; Docherty, Sharon PhD; Portlock, Jane C. PhD; Safety of Chiropractic Manipulation of the Cervical Spine; A Prospective National Survey; Spine; Volume 32(21), October 2007, pp 2375-2378.)
• The largest study to date concluded that chiropractic cervical spine adjusting is not associated with adverse vascular events. (Cassidy, J David DC, PhD; Boyle, Eleanor PhD; Côté, Pierre DC, PhD; He, Yaohua MD, PhD; Hogg-Johnson, Sheilah PhD; Silver, Frank L. MD; Bondy, Susan J. PhD; Risk of Vertebrobasilar Stroke and Chiropractic Care: Results of a Population-Based Case-Control and Case-Crossover Study; Spine; Volume 33(4S), February 15, 2008 pp S176-S183.)

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